Jack S. Summers

Jack Summers


Department of Chemistry and Physics
Associate Professor, Inorganic Biochemistry

Phone: 828-227-3668
Email: summers@email.wcu.edu
Office Address: 408 Stillwell Science Building


Ph.D., Georgia Institute of Technology

B.Sc., University of West Florida

Area of Interest:

Biophysical chemistry related to oxidative stress; chemical kinetics; inhibition of Superoxide Dismutase enzymes by low molecular weight compounds; role of metal ions in the antibiotic behavior of medicinal clays.

Selected Publications:

T. M. Cunningham, J. Koehl, J. S. Summers, S. E. Haydel. "pH-dependent metal ion toxicity influences the antibacterial activity of two natural mineral mixtures." PLoS ONE, 2010 (doi: 10.1371/journal.pone.0009456).

Jack S. Summers*, Joseph B. Baker, Dan Meyerstein, Amir Mizrahi, Israel Zilberman, Haim Cohen, Christopher M. Wilson, Jamie R. Jones, "Measured Rates of Fluoride / Metal Association Correlate with Rates of Superoxide / Metal Reactions for Fe IIIEDTA(H2O)¯ and Related Complexes." J. Amer. Chem. Soc., 2008, 130, 1727.

Jack S. Summers, US Patent Application, Methods for predicting the reactivities of metal complexes toward catalyzing biological oxidation / reduction reactions. Full patent application filed September, 2008. Provisional application filed September, 2007.

Jack S. Summers, Anthony Giordano, Michael Sturgess, and John Shimko, Methods for detecting and quantifying binding and inhibition of binding of species to nucleic acids. US Patent #US 7,037,660 B2, May 2, 2006.

Jack S. Summers*, Karel Base, Hakim Boukhalfa, Jason E. Payne,1 Barbara Ramsay Shaw, and Alvin L. Crumbliss, “The Use of Phosphorus Ligand NMR Probes to Investigate Electronic and Second-Sphere Solvent Effects in Ligand Substitution Reactions at Manganese(II) and Manganese(III),” Inorg. Chem., 2005, 44, 3405-3411.

Jack S. Summers,* John Shimko, Fredric L. Freedman, Christopher T. Badger, and Michael Sturgess, “Displacement of Mn2+ from RNA by K+, Mg2+, Neomycin b, and an Arginine Rich Peptide: Indirect Detection of Nucleic Acid/Ligand Interactions using Phosphorus Relaxation Enhancement (PhoRE),” J. Am. Chem. Soc., 2002, 124, 14934-14939.

Jack S. Summers*, Charles G. Hoogstraten, R. David Britt, Karel Base, Barbara Ramsay Shaw, Anthony A. Ribeiro, and Alvin L. Crumbliss, “ 31P NMR Probes of Chemical Dynamics: Paramagnetic Relaxation Enhancement of the 1H and 31P NMR Resonances of Methylphosphite and Methylethylphosphate Anions by Selected Metal Complexes,” Inorg. Chem., 2001, 40, 6547-6554.

Jack S. Summers and Barbara Ramsay Shaw, “Boranophosphates as Mimics of Natural Phosphodiesters in DNA,” Curr. Med. Chem. 2001, 8, 1147-1156.

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