Maria Gainey

Lecturer

Email: mdgainey@email.wcu.edu
Office: 333 Natural Sciences Building

Education:

  • Postdoctoral Trainee Washington University Medical Center
  • Ph.D. Microbiology and Immunology Wake Forest University School of Medicine
  • B.S. Biology/Chemistry, Studio Art minor Appalachian State University

Courses Taught:

  • Biology 493/Chemistry 493 PHAGE Hunters
  • Biology 493/593: Virology Course
  • Biology 414/514 Methods of General Microbiology
  • Biology 333: Cell and Molecular Biology Lab
  • Biology 140: Principles of Biology I Lab
  • Chemistry 132: Survey of Chemistry I Lab
  • Chemistry 333 Survey of Chemistry II Lab

Research Interests:

Immunology, Virology, Bacteriophage Genomics, and Virus-Host Interactions

Publications:

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson BR, Ratushny AV, Litvak V, Dabelic R,Manicassamy B, Aderem A, Richard M, Elliott RM, Garcia-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. Selective viral targeting by interferon effectors defines a requirement for cGAS in antiviral immunity. Nature 2014 Jan; 505(7486).

Gainey MD, Rivenbark JG, Cho H, and Yang L, and Yokoyama WM. Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming. PNAS 2012 Nov; 109(47).

Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M Jr, Virgin HW, Klein RS, Sen GC, and Diamond MS. 2’-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and independent mechanisms of host restriction in vivo. PLoS Pathogens 2012 May;8(5).

Pinto AK, Daffis S, Brien JD, Gainey MD, Yokoyama WM, Sheehan KC, Murphy KM, Schreiber RD, and Diamond MS. A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection. PLoS Pathogens 2011 Dec;7(12).

Gainey MD, Manuse MJ, and Parks GD. A hyper-fusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon. J. Virology 2008 Oct;82(19):9369-80.

Gainey MD, Dillon PJ, Clark KM, Manuse MJ, and Parks GD. Paramyxovirus induced shut off of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation. J. Virology 2008 Jan;82(2):828-39. (Selected as a spotlight article).

Wansley EK, Dillon PJ, Gainey MD, Tam J, Cramer SD, and Parks GD. Growth sensitivity of a recombinant simian virus 5 P/V mutant to type I IFN differs between tumor cell lines and normal primary cells. Virology 2005 Apr 25;335(1):131-44.

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