College Of Health & Human Sciences

Research

Student conducting mosquito research in the forest

 

La Crosse Encephalitis

Our research primarily focuses on domestic mosquito-borne diseases in the western North Carolina region. We use an eco-epidemiological approach to current and emerging issues. Specifically, our principle research activities focus on La Crosse Encephalitis. This viral disease is responsible for the majority of human mosquito-borne disease in NC and is found predominately in the western counties. We have developed a strong collaboration with Dr. Gideon Wasserberg (UNC-Greensboro) to address fundamental questions of how human behaviors (e.g., anthropogenic impacts) increase the risk of exposure to La Crosse virus in western NC.

Every summer, local children (typically less than 16 years old) end up in hospital intensive care units suffering from La Crosse encephalitis, a viral infection and inflammation of the brain. The cause of this illness: the bite of mosquito infected with La Crosse virus. Although death is rare (Case Fatality Rate <1%), the social and economic burden of the disease is high, especially when life-long disabilities result from the infection ( Utz et al, 2003). In general, the annual number of recognized La Crosse encephalitis cases in western North Carolina appears to be increasing. However, these recognized cases represent the “tip of the iceberg” in terms of virus transmission. For every one recognized case of La Crosse encephalitis, it is likely that many, many more individuals were exposed to the virus through a mosquito bite. In addition, it is likely that a substantial number of clinically apparent La Crosse virus infections that occur each year in NC are not diagnosed.

Frequently Asked Questions 

What causes La Crosse Encephalitis?

The disease is caused by a virus (La Crosse virus) that is transmitted by the bite of a mosquito.

What is Encephalitis?

Encephalitis is an inflammation of the brain (encephalon = brain).

Additional information about La Crosse Encephalitis (including maps and mosquito fact sheets) may be found here.(NC Department of Health and Human Services, Division of Public Health)

What can I do to prevent La Crosse Encephalitis?

  • Use an approved repellent according to the directions on the label
  • Avoid peak biting hours (approximately 2 hours before and after dusk and dawn)
  • Wear protective clothing
  • Reduce “breeding” sites around your house
  • Repair screen windows and doors

More information about prevention may be found here. (Centers for Disease Control and Prevention)

Where can I find more information about La Crosse Encephalitis?

  • The Centers for Disease Control and Prevention maintains the following webpage dedicated to La Crosse Encephalitis: http://www.cdc.gov/lac/

Mosquito identification cases

 

Taxonomy

We also investigate unresolved taxonomic questions within the Culicidae using both molecular and morphological approaches. Additional studies involve the use of molecular techniques to validate morphological characters to distinguish mosquitoes that are often difficult to identify by microscopy. Using DNA sequencing, we (Harrison et al) have validated a novel morphological character to separate the adult females of Aedes (Ochlerotatus) atlanticus and Aedes (Ochlerotatus) tormentor. Additional studies are underway validating morphological characters to identify field collected Culex pipiens and Culex restuans.

Invasive Species

In addition, we also collaborate with Dr. George O’Meara (University of Florida) investigating the impact of an invasive mosquito species ( Aedes japonicus) from Southeast Asia on our native rock pool mosquito (Aedes atropalpus) populations. Our studies on the impact of this invasive mosquito species have demonstrated the dynamic nature of mosquito-borne disease ecology. This mosquito is now found in high abundance in western NC and has likely displaced a native mosquito species. The public health implications of this invasion are profound because the invasive species is known to be capable of transmitting La Crosse virus.

Office of Web Services