Jason A. Clement
Department of Chemistry and Physics
Assistant Professor, Natural Products Chemistry
Phone: 828-227-2717
Email: jclement@email.wcu.edu
Office Address: 210 Natural Sciences Building
Website: http://paws.wcu.edu/jclement
Education:
- Ph.D., Virginia Polytechnic Institute and State University, 2005
- B.S., Western Carolina University, 2000
Areas of Interest:
Antitumor and antibacterial natural products drug discovery; phytochemical analysis of botanical medicinal products and plants indigenous to Appalachia; natural products synthesis
Selected Publications:
- Beutler, J. A.; Kang, M.-I.; Robert, F.; Clement, J. A.; Pelletier, J.; Colburn, N. H.; McKee, T. C.; Goncharova, E.; McMahon, J. B.; Henrich, C. J. Quassinoid Inhibition of AP-1 Function Does Not Correlate with Cytotoxicity or Protein Synthesis Inhibition. J. Nat. Prod. 2009, 72, 503-506.
- Clement, J. A.; Kitagaki, J.; Yang, Y.; Saucedo, C. J.; O’Keefe, B. R.; Weissman, A. M.; McKee, T. C.; McMahon, J. B. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg. Med. Chem. 2008, 16, 10022-10028
- Clement, J. A.; Li, M.; Hecht, S. M.; Kingston, D. G. I. Bioactive Isomalabaricane
Triterpenoids from Rhabdastrella globostellata that Stabilize the Binding of DNA Polymerase
ß to DNA. J. Nat. Prod. 2006, 69, 373-376.